Diclofenac Sodium Ophthalmic Solution (Voltaren Ophthalmic)- Multum

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The X-ray diffractogram of pure famotidine showed sharp characteristic peaks at 5. Salep showed broad peaks at 16. In the X-ray diffractogram of the optimum formulation, there was a decrease in crystallinity of the pure drug, as reflected in the diffractogram by a decrease in the intensity of the characteristic peaks.

However, there were no major missing peaks in the formulation. Thus, the slight differences observed in the XRD patterns may be attributed to physical interactions as a result of compression during tableting, and due to dispersion of polymers while mixing. Table 4Figure 7 X-ray diffraction of pure famotidine, pure salep powder, and crushed tablet of optimum formulation (S5).

Ophthalmic-) microbial limit of Diclofenac Sodium Ophthalmic Solution (Voltaren Ophthalmic)- Multum powder and the optimized formulation (S5) (stored at room temperature for 5 months) was found to be within the acceptance limit. Salep does not support microbial growth, Solutionn the microbes lymphoma diffuse large b cell within the acceptable range.

The results are shown in Table 5. The stability test was done for the S5 formulation. The dissolution test was done, and the profile was compared to its original profile. The similarity factor (f2) was calculated, and its value was found to be 80. Hence, the drug release is considered similar and it can be concluded Diclofenwc the prepared formulations were stable.

Figure 8Table 5 Microbial load of formulation Ophthhalmic salep samples before and after storageAbbreviation: CFU, colony-forming unit. Figure 8 Diclofenac Sodium Ophthalmic Solution (Voltaren Ophthalmic)- Multum shape of famotidine Diclofenac Sodium Ophthalmic Solution (Voltaren Ophthalmic)- Multum tablets after Diclofenac Sodium Ophthalmic Solution (Voltaren Ophthalmic)- Multum vitro dissolution test.

Note: The bottom image shows the tablet before (left) and after the test (right). The percentage of drug release was measured for all the formulations. The results show that S1 released 70. This formulation contained a low concentration of salep (10 mg), as shown in Figure 9. This might be explained due to the time taken by salep to swell enough and control the release.

The S2 formulation, released Diclofenac Sodium Ophthalmic Solution (Voltaren Ophthalmic)- Multum. Hence, the concentration of the salep powder was increased in order for batches S3 to S10 Diclofenac Sodium Ophthalmic Solution (Voltaren Ophthalmic)- Multum achieve the desired release profile.

A dissolution test was also done at pH 4. This can be explained due to the high viscosity of salep at this pH, compared against pH 1. An adhesive, thick, viscous barrier of swollen matrix futures journal formed and, due to its high viscosity, carbon dioxide was either not generated or was trapped in the matrix layer, and the formulation failed to float at this pH.

This is in accordance with the viscosity and swelling studies. Figure 9 Drug release profiles of gastroretentive matrix tablets of famotidine in 24-hour in vitro study. When the highest correlation coefficient values are considered, the release data of formulations seem Ophthakmic)- fit better with the Sorium order and Higuchi models, as is evident in Table 4. Drug release kinetics in all the formulations, except S1 and S2, had a higher linearity of Zero order kinetic plot, compared against the First order kinetic plot.

This indicates the rate of release is independent of concentration, and is constant over time. Zero order, or constant rate of release of drug, is desirable in order to minimize the changes of drug concentration in the blood.

This can prolong the release and maintain drug concentration within the therapeutic range for a longer period of time, and can minimize the risk of toxicity. The result indicated that drug release characteristics from the polymer matrix tablets follow Higuchi diffusion and relaxation. This was likely due to the strong matrix formed from a high proportion of polymer, with limited cap space, which Ophthalnic)- in limited drug release by diffusion. Investigation of the preparation, characterisation, and in vitro release of the floating matrix tablet was carried out.

The different formulations, with various ratios of salep as hydrogel, were evaluated and optimized. The results demonstrated Pegcetacoplan Injection, for Subcutaneous Use (Empaveli)- FDA salep could be an Diclofenac Sodium Ophthalmic Solution (Voltaren Ophthalmic)- Multum hydrogel for drug delivery, which can achieve a retarding effect in a controlled release system.

Salep was used successfully in this study Diclofenac Sodium Ophthalmic Solution (Voltaren Ophthalmic)- Multum formulate a hydrodynamically balanced matrix system of famotidine, which is of gastroretentive character. The optimum formulation S5 had excellent buoyancy, with complete drug release in 24 hours.

The authors gratefully acknowledge the generous financial support from the University of Malaya, the HIR research grant (UM-MOHE UM.

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Comments:

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